Biosensors & Bioelectronics

Biography

Biography: Anis Rahman

Abstract

Terahertz scanning reflectometry enables investigating both the surface and the sub-surface of biological tissues in non-invasive fashion. T-ray is non-ionizing, thus, eliminates radiation damage of sensitive tissues while still probing disease conditions in the deeper layers leading to an effective early diagnostic tool. In this study, terahertz techniques have been developed that is comprised of terahertz scanning reflectometry, terahertz time-domain spectroscopy and terahertz 3D imaging (all instruments from Applied Research & Photonics, Harrisburg, PA 17111) for detection of basal cell carcinoma (BCC) in comparison with the benign skin samples. Benign skin biopsy samples and the biopsy from cancerous area were investigated. Thickness profiling exhibits significant differences in profiles of the respective skin samples both in their layer structure and also in their total reflected intensities; thus indicating presence and lack of cellular order for the respective specimens. Terahertz spectra, acquired in transmission, exhibit quantifiable differences for both groups. Additionally, 3D terahertz image of the benign skin shows regular cell patterns while the images of BCC sample exhibit irregular and agglomerated cell patterns. The lack of cellular order in the skin, thus, may be used as an indication of cancer forming process. This finding, therefore, may be used as an early diagnostic tool. It is notable that this is the first of such a concerted observation of benign versus BCC skin samples from three different experiments. The results are consistent from individual experiments and collectively provide an accurate means of early detection of BCC.