Day 1 :
Eastern Virginia Medical School, USA
Time : 10:30 - 11:00
C Donald Combs, PhD serves as Vice President and Dean, School of Health Professions, at the Eastern Virginia Medical School (EVMS). He holds faculty appointments as tenured Professor of Health Professions at EVMS, Professor of General Medicine at the State Medical and Pharmaceutical University “Nicolae Testemitsanu”, Visiting Professor of Medical Simulation at University of Paris—Descartes and as Adjunct Professor of Modeling, Simulation and Visualization Engineering at Old Dominion University. From 1996 to 2002, he also served as a Senior Fellow at the US Naval Postgraduate School.
The dramatic growth in data about the human body and the human in social context combined with the progress in informatics, and modeling and simulation present an opportunity to realize a thirty-year old vision for a virtual human. This virtual human, however, will be far more sophisticated than the initial vision in that it will be capable of serving as a platform for research, education, patient care, drug and device testing. It will also be capable of accurately representing individuals and populations over time for purposes of screening, prevention, treatment, and analysis. The more accurate descriptor is to think in terms of a digital patient platform with infinite combinatorial possibilities. The objectives of this presentation are to provide an update on the status of a variety of international research efforts to extend human physiome research to include the social, behavioral and societal systems necessary to construct the digital patient and to discuss the opportunities to developing new models and simulations that will use the digital patient platform. The goal of the digital patient is to develop a database, software and analytic framework that integrates biological systems (body, organ, tissue, cells, molecules), a variety of scientific disciplines (biology, physiology, biophysics, biochemistry, molecular biology, bioengineering or social science), anatomical sub-system (cardiovascular, musculoskeletal, gastrointestinal, etc.), social context and data analytics. This presentation provides an overview of the major research initiatives that are underway, and the challenges that must be addressed, particularly in the use of biosensors and the aggregation of data into usable formats.
University of Edinburgh, UK
Time : 11:00 - 11:30
Mark Bradley was made a Professor of Combinatorial Chemistry in 1996. He has been elected to fellowships of both the Royal Society of Chemistry and Edinburgh and has awarded a number of prizes such as the Novartis Chemistry Lectureship, the Award from the Society of Combinatorial Sciences, the 2015 Royal Society of Chemistry Tilden Prize. His group has published over 300 peer reviewed papers and more than 60 PhD students have graduated from his group. He holds an ERC Advanced grant and is PI on £18M of active grants. He has published over 300 peer reviewed papers, filed some 20 patents and is co-founder of Ilika Technologies (IPO on AIMS May 2010) and of Edinburgh Molecular Imaging (2014). rn
Electrochemical, peptide-based, biosensors are attracting significant attention for the detection and analysis of proteins. Among them, proteases are interesting targets due to their relevance in many pathophysiological conditions, including inflammation and cancer. Different platforms have been suggested for the electrochemical detection of these enzymes, as they catalyze the cleavage of amide bonds at specific sites in a protein or peptide. To meet the increasing demand for selective and sensitive analytical tools for the detection of proteases, improved analytical features, such as reduced limits of detection and sensor stability, are important. Here we investigate the effect of the nature and length of a spacer on the sensitivity of the electrochemical sensor. Redox-tagged peptides, tethered to a gold surface through a self-assembled monolayer (SAM), were selected as the Biosensing platform for the electrochemical detection of protease activity.
Bielefeld University, Germany
Time : 11:45 - 12:15
Andreas Hütten has completed his PhD in Physics from Göttingen University in Germany and was working as a Feodor Lynen Research Fellow at UC Berkeley and Lawrence Berkeley National Laboratory in the US and in Germany at the Leibnitz Institute for Solid Sate and Materials Research Dresden. He is Professor of Thin Films and Physics of nh at the Department of Physics at Bielefeld University in Germany. He has published more than 190 papers in reputed journals and is serving as an Editorial Board Member for sensors.
Lab-on-a-chip immunoassays utilizing super paramagnetic beads as labels allow for transport, separation and detection of different bead species by employing magnetic strayfield landscapes and/or special channel geometries in microfluidic systems in combination with integrated magnetoresistive sensors. Moreover, the formation of magnetic bead superstructures due to dipolar magnetic interactions can be applied as configurable matter so as to realize programmable microfluidic functions such as mixers, filters or valves which are able to simultaneously detect biomolecule via molecular recognition. This lecture is focused on physical aspects regarding microfluidics and the formation of magnetic bead superstructures which play an important role on the way to magnetically controlled lab-on-a-chip structures. Moreover, the realization of giant magnetoresistive Biosensors based on these magnetic bead super structures will be discussed in detail.