Day 1 :
Graz University of Technology, Austria
Time : 10:00-10:40
Christian Baumgartner is a Professor and Head of the Institute of Healthcare Engineering with European Testing Center of Medical Devices at Graz University of Technology, Austria. He is the author of more than 150 publications in refereed journals, books and conference proceedings. He is a Reviewer for more than 40 scientific journals, and conference proceedings, book and grant proposals and serves as deputy and series Editor as well as an Editorial Board Member of several scientific journals. His main research interests include “Biomedical sensors, cellular electrophysiology and signal processing, biomedical modeling and simulation, and clinical bioinformatics”
A new optical, adaptable, multi-functional, high-resolution three-axis sensor is presented. The sensor can replace standard joysticks in medical devices such as electric wheelchairs or surgical robots and may also serve for navigation in the aerospace or marine sector. A laser diode is affixed to a movable axis and projects and interprets a random geometric shape on a CMOS or CCD chip. The downstream microcontroller’s software identifies the geometric shape’s center, distortion and size, and subsequently calculates x, y, and z coordinates, which can be processed in attached devices. Depending on the image sensor in use (e.g., 6.41 megapixels), the 3-axis sensor features a resolution of 1544 digits from right to left and 1038 digits up and down. Through interpolation, these values rise by a factor of 100. The movement carrier is positioned in a polymer sandwich which is capable of absorbing a large spectrum of forces upon it (approximately 1 g to 5 kg) and the carrier and thus the axis of the sensor can be moved by <1° in any direction. The sensor features excellent reproducibility in terms of deflection to coordinates and the ability to return to its neutral position very precisely. Further properties are the high level of protection against electromagnetic and radio frequency interferences, and the adaptability and adjustability to fit a user’s range of motion with respect to stroke and force. This new sensor device thus aims to optimize sensor systems such as joysticks in terms of safety, ease of use, and adaptability.
Bundeswehr Institute of Radiobiology, Germany
Keynote: Establishing gene expression for early and high-throughput prediction of the hematological acute radiation syndrome
Time : 11:00-11:40
Michael Abend completed his Medical doctor degree at University of Cologne; a Professorship in Radiobiology at Technical University Munich and; studied Epidemiology at Gutenberg University in Mainz, Germany. He worked at different Institutions such as: Armed Forces Radiobiology Research Institute, Bethesda and National Cancer Institute (Radiation Epidemiology Branch), Rockville, USA. He received several scientific awards and published about 100 peer reviewed scientific papers. He is currently a Deputy Director and Leader of Genomic department at Bundeswehr Institute of Radiobiology
We aimed to predict occurrence of hematological acute radiation syndrome (HARS) and its severity based on early detected changes in gene expression. Using peripheral blood from baboons irradiated with 2.5 or 5 Gy (whole body equivalent dose), we examined changes in gene expression occurring one and two days after exposure in relation to unexposed blood samples (pre-exposure samples). Utilizing whole genome microarrays and validating candidate genes with qRT-PCR finally allowed us to identify a set of 29 baboon genes forwarded for cross-species validation using human samples. Within this presentation, we will provide first results on this cross-species validation and share preliminary results on our envisioned 1,000 sample exercise to examine the feature of high-throughput diagnostic of the HARS using gene expression
SensDx Ltd, Poland
Time : 11:40-12:20
Dawid Nidzworski is an Entrepreneur and Scientist. He completed his Graduation at Faculty of Chemistry, Gdansk University of Technology (GUT), Poland and Intercollegiate Faculty of Biotechnology of the University of Gdansk and Medical University of Gdansk (IFB UG-MUG). He also completed his PhD at IFB UG-MUG. He developed biosensor (FluSensDx) which will identify influenza virus in the patient's throat swab. He is also working on an edible vaccine against influenza virus for poultry (LIDER). He has received many awards and scholarships. He is Co-author of several publications, congress reports and patent applications. His start-up company SensDx will revolutionize the way of medical diagnostics in the world
Influenza is a contagious disease caught by humans and caused by viruses belonging to the family Orthomyxoviridae. Each year, the influenza virus infects millions of people and kills hundreds of thousands of them. Economic losses caused by employee absenteeism are counted in the hundreds of millions of dollars a year. In order to successfully treat influenza virus infections, it is necessary to detect virus during initial development phase of the infection when tens to hundreds of viruses are present in pharynx of the patient. Here, we show a new universal diamond biosensor which enables detection of the virus at ultralow concentration even before clinical symptoms. A diamond electrode is modified with polyclonal anti-M1 antibodies and then a universal biomarker of influenza virus – M1 protein can be captured. In this assay, we observe a change in electrochemical impedance spectra. A detection limit of 1×10-14 g/mL in saliva buffer is achieved with M1 biomarker corresponds with 5-10 virus particles in samples. Also the universality of the assay was confirmed analyzing different strains of influenza A virus.