Alok Pandya
Ahmedabad University, India
Title: Supramolecular nanoassembly as optical biosensing platform
Biography
Biography: Alok Pandya
Abstract
The principles and phenomena outlined within this talk is based on supramolecular nanochemistry which can lead to intricate and complex designs that form the heart of the many facets of supramolecular nanoassembly. Detection of chemical and biological agents plays a crucial role in medicinal field, forensic, agricultural, and environmental and electronics. Thus, the challenges in development of novel detection systems have been concerned with getting better the recognition process as well as designing pioneering assemblies. Supramolecular nanoassemblies provide novel systems for the pursuit of new recognition and transduction processes, as well as increasing the signal-to-noise ratio through efficiency of the system components. Thus, selective detection of biologically relevant molecule have enormously gained its attention due to involvement in variety of fundamental environmental and biological process in organism because its deficiency and excess can induce a variety of diseases. Therefore, biomolecule detection has received a great deal of study. Here, we have designed an efficient strategy using supramolecular nanoassembly to detect biologically relevant small molecules. In our method, we developed a microwave assisted new promising approach using Silver (Ag) and Gold (Au)nanoparticles (NPs) based colorimetric sensing system(ANCSS), which form calix[4]arene-functionalized Ag and Au nanoprobe complex (CX-AgNPs/AuNPs) for the detection of biologically relevant small molecules such as creatine, ferric ion and glucose in water. The key to the successful formation of this strategy is multi binding site of functionalized calix[4]arene which sensitively and selectively target to small molecules. The developed biosensor has been proved to be a simple, reliable and accurate method to assist towards point of care diagnostics.