Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 10th International Conference & Exhibition on Biosensors & Bioelectronics Dallas, Texas, USA.

Day 2 :

Keynote Forum

Mahi R. Singh

Professor, University of Western Ontario, Canada

Keynote: Applications of Metallic Nanoparticles in Biosensors and Bioelectronics

Time : 10:00-10:45

Conference Series Biosensors & Bioelectronics 2018 International Conference Keynote Speaker Mahi R. Singh photo
Biography:

Mahi R Singh working as a professor since 1985 at The University of Western Ontario which is one best and largest Universities in Canada. He was a Royal Society Professor at Oxford University and worked in High Magnetic Lab in Toulouse. He was Chief researcher at Hitachi Research Lab in Tokyo. He also worked at McGill University, Montreal with P.R. Wallace who invented Graphene theoretically in 1947. He have very active research group and have produced many graduate students/postdocs who are professors all over the world. He have international theoretical and experimental collaborations in US, UK, Spain, Italy, Sweden, China, Germany, India, Egypt, Argentina, and Mexico. For example, He is developing collaboration with Klaus von Klitzing and he is visiting him next summer. Recently he have organized about 16 international conferences and hosted three Nobel Laureates (Klitzing, Leggatt and Yonah). He have been invited as plenary and invited speaker throughout the word. Since 2003, he have presented about 100 public, plenary and invited talks in many international conferences and universities in the world. He has published about 300 papers and 10 books in condensed matter physics, optoelectronics, plasmonics, nanophotonics, nanomaterials, nano-hybrids and metamaterials.

Abstract:

Recently there is considerable interest to study metallic nanoparticle for the application of biosensors and bioelectronics [1-4]. Noble-metal nanoparticles are known to enhance emission rates of quantum emitters (QEs) significantly by decreasing their radiative lifetime and increasing their quantum yield [1-2]. The enhancement of the emission in QEs such as molecular fluorophores is a highly useful strategy for improving detection sensitivity and selectivity in many emerging applications in biosensors and bioelectronics, and DNA screening. Recently, there is considerable interest to study hybrid systems made of biocompatible fluorescent molecules and metallic double nanoshells (DNSs) for biomedical imaging and for the detection of disease markers in the near-infrared wavelength region. The penetration depth of near-infrared light is large in most biological media. It is found that these hybrids have large absorption coefficients and high quantum yields in the far-infrared region. Here we study the light emission from quantum emitter and double metallic nanoshell hybrid systems. Quantum emitters act as local sources which transmit their light efficiently due to double nanoshell near field. The double nanoshell consists a dielectric core and two outer nanoshells. The first nanoshell is made of a metal and the second spacer nanoshell is made of a dielectric material or human serum albumin. We have calculated the fluorescence emission for a quantum emitter-double nanoshell hybrid when it is injected in an animal or human body. The outer spacer nanoshell of double metallic nanoshells consists of silica and human serum albumin with variable thickness. We find that the thickness of the spacer nanoshell layer increases the enhancement when the fluorescence decreases. The enhancement of the fluorescence depends on the type of quantum emitter, spacer layer and double nanoshell. We also found that the peak of the fluorescence spectrum can be shifted by changing the shape and size of the nanoshell. The fluorescence spectra can be switched from one peak to two peaks by removing the degeneracy of excitonic states in the quantum emitter. Hence using these properties, one can use these hybrids as biosensing and switching devices for applications in bioelectronics.

Break:

Networking & Refreshment Break: 10:45-11:00

  • Sessions: Biosensors for Imaging | Environmental Biosensors | Bioinstrumentation | Advancement in Nanotechnology | BioMEMS/NEMS | Gas Sensors | Bioengineering Applications
Location: Franklin
Speaker

Chair

Tom Zimmermann

Michigan State University, USA

Speaker
Biography:

Ridwan Fayaz Hossain is a Ph.D. candidate in Electrical Engineering department at University of North Texas. His Ph.D. research is focused on ink-jet printing of 2D layered materials for flexible and printed electronics, with a particular emphasis on bio-related applications and bioelectronics. He has published more than 15 papers in reputed journals (Nature 2D materials and Application, 2D Materials, Journal of Materials Chemistry C, Biomedical Microdevices etc.).

Abstract:

Age-related macular degeneration (AMD), a retinal degenerative disease that results in a continuous degeneration of photoreceptors in the retina which eventually leads to complete blindness. One approach to combat AMD is through the use of artificially implantable photodetectors that are physically placed on the retina. The large format photodetector pixels on the flexible and conformable substrate allows the implantable photodetectors to be in intimate contact to retinal pigment epithelium. Interestingly, 2D materials such as photosensitive and semiconducting molybdenum disulfide (MoS2) and electrically conducting graphene have recently received tremendous promise due to their unique photonic and optoelectronic properties properties and their potential in various types of micro and nano devices. In this study, we have tested the biocompatibility of various 2D materials, such as graphene and MoS2 in several organic solvents. Specifically, these materials have been dispersed in Isopropyl Alcohol (IPA), a mixture of Cyclohexanone/Terpineol 7:3 ratio (C/T), and N-Methyl-2-pyrrolidone (NMP). Mouse Embryonic Fibroblast (STO) was used for the biocompatibility analysis for inks drop cast on flexible polyimide substrate. The inks formed using 2D graphene and MoS2, were highly biocompatible on polyimide substrates, where a cell survival rate of up to 98% was measured for the STO, while the cell confluence rate was in between 70-98%. Here, a new approach was utilized to form photosensitive pixels that utilize heterostructures of inkjet printed MoS2 and graphene, using inks that also show a high degree of biocompatibility. The inkjet printed 2D heterostructure devices were photoresponsive to broadband incoming radiation in the visible regime, and the photocurrent scaled proportionally with the incident light intensity, exhibiting a photoresponsivity R ~ 0.30 A/W.  This is 103 times higher compared to prior reports, and detectivity D was calculated to be ~ 3.6 × 1010 Jones at room temperature. Strain-dependent measurements of photocurrent with bending was also conducted, that showed a photocurrent of ~ 1.16 µA with strain levels for curvature up to ~ 0.262 cm-1, indicating the feasibility of such devices for large format arrays printed on flexible substrate, unlike conventional Si implantable detectors that are rigid and nonconformable. In conclusion, the inkjet printed, biocompatible 2D hetero-junction photodetector formed on flexible and conformable substrates was successfully shown to be photoresponsive to a wide range of light intensities and strain levels, making it a promising prospect for in vivo bio-sensing applications for AMD.