7^th Euro Biosensors & Bioelectronics Congress

Biography

Biography: Asrulnizam Abd Manaf

Abstract

Implementation of simple fluidic-based memristor sensor in bio-sensing application was presented. The sensor was fabricated using sol-gel spin coating technique and has nine wells functions to increase the conjugation area to trap virus. The sensor fabricated in four sizes wells diameter of 0.5 mm, 1 mm, 1.5 mm and 2 mm. The sensors were modified with anti-dengue virus NS1 glycoprotein monoclonal antibody before applied with dengue virus 1 virus NS1 glycoprotein full. Four concentration’s dengue viruses of 52 nM, 104 nM, 208 nM and 416 nM prepared and applied to the modified sensor. The ability of the sensor in sensing dengue virus is measured using the off-on resistance ratio to represent the loop area. The results show that the loop area of the pinched hysteresis loop increase as the dengue virus applied to the modified sensor. The loop area also increases as the concentration of the dengue virus increases. The most obvious change in loop area observed for 416 nM dengue virus. The recorded sensitivity for the 2 mm wells diameter is 6.53×10^-3 (nM)^-1 which measured in fluidic-based platform. This concludes that the dengue virus produced reaction with the modified sensor and thus changes the sensors behaviors.