14^th Euro Biosensors & Bioelectronics Congress

Nucleic Acid Sensors

Nucleic Acid Sensors presents a well-timed and extensive account of the detection of nucleic acids in contamination and inflammation. Nucleic acid sensors additionally understand endogenous nucleic acids, for example when cells are broken by genotoxic agents and in positive auto-inflammatory diseases.  Proteins called RNA and DNA sensors detect foreign nucleic acids and, in mammalian cells, include RIG-I, cGAS, and AIM2. On binding to nucleic acids, these proteins initiate signalling cascades that activate host defense responses. An important aspect of this defense program is the production of cytokines such as type I interferons and IL-1β. Studies conducted over recent years have revealed that nucleic acid sensors also activate programmed cell death pathways as an innate immune response to infection. Indeed, RNA and DNA sensors induce apoptosis, pyro ptosis, and necroptosis