Day 2 :
Center for Pharmaceutical Engineering (PVZ), Germany
Keynote: Microfluidic systems for pharma technology - the manipulation of cells, droplets and particles
Time : 09:00-09:40
Andreas Dietzel studied Physics and completed his PhD at University of Göttingen in 1990. In the years 1990 to 2003, he worked in different organizations of IBM including the Research Laboratory in Rüschlikon. In 2004, he joined TU Eindhoven as a Full Professor of Micro and Nanoscale Engineering. In 2012, he was appointed as Professor at TU Braunschweig and Director of the Institute of Micro-technology. His research interest focuses on “The design and fabrication of microsystems and especially of microfluidic systems with applications in the life sciences”
In a world that becomes increasingly concerned about affordable health care, fast and effective screening methods for drugs in different formulations are required in the course of their development. In addition, the trend towards personalized medicine demands production of drugs in very small volumes. For both, the microfluidic approach is ideally suited. With miniaturized systems that can be realized by micro- or nanofabrication processes, new tools for pharmaceutical research and development become available. As new and better technologies for pre-clinical screening of drug dosage formulations microfluidic cell culture models that can mimic in-vivo conditions have attracted much attention. Recently developed organ-on-chip platforms providing dynamic flow conditions like cornea-on-chip and pancreas-on-chip will be presented including aspects of their microfluidic design, their fabrication and application. These systems are equipped with integrated sensors but also allow microscopic access at low background auto fluorescence. Furthermore recent work on the production of nanoparticles formulations within microfluidic droplet flows and plug flows will be discussed. In thereby obtained smallest fluid volumes mixing is accelerated and very controlled precipitation occurs. This leads to nanoparticle formulations in which particle sizes can be tuned by external flow controls. These approaches offer new possibilities for production at smallest scales and for improving the bioavailability of poorly soluble drugs.
Tsinghua-Berkeley Shenzhen Institute, China
Time : 09:40-10:20
Xiaohao Wang completed his Bachelor and Doctor degree both at Tsinghua University in 1994 and 1999, respectively. From 1998, he worked at Tsinghua University as a Faculty member, and was promoted to Full Professor at 2000. From 2007 to 2008, he was at Technical University of Berlin as a Visiting Scholar. He serves as the Deputy Dean of Graduate School at Shenzhen, Tsinghua University, now. His research interests cover MEMS based sensors and actuators, ionizing sources and portable analytical instrument. He has published over 200 technical papers and holds tens of patents.
Ionization source is a vital component of the mass spectrometer. In recent years, with the development of the mass spectrometer miniaturization and the microfluidic chip integration technologies, increasing research efforts have been devoted to the coupling of microfluidic chip ionization source to mass spectrometry. Facing requirement of portable MS used for on-site rapid detection, a microfluidic chip ionization source is developed. Multi-layer soft photolithography technology is chosen as the fabrication craft for the microfluidic chip template, and three novel microfluidic chip ionization sources were proposed, such as a microfluidic chip-based multi-channel ionization (MCMCI) was developed to extend the application of microfluidic chip ionization to MS. This MCMCI implemented extraction of untreated compounds in complex matrices without sample pretreatments and dual sprays with high DC voltages simultaneously.